Standard: API 37-31487

CHO/HGPRT MUTATION ASSAY OF COMMERCIAL HEXANE

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Scope:

INTRODUCTION

Mammalian cell culture systems provide a valuable tool for assessing the genetic hazards of a variety of potentially Imltagenic agents. The CHO/HGPRT mutation assay was designed to select for Imltant cells which have become resistant to the purine analogue 6-thioguanine as a result of mutation at the X-chrorrosome-linked hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus of Chinese hamster ovary (CHO) cells. This system has been demonstrated to be sensitive to the Imltagenic action of a variety of chemicals (1).

Organization: American Petroleum Institute
Document Number: api 37-31487
Publish Date: 1990-04-01
Page Count: 38
Available Languages: EN
DOD Adopted: NO
ANSI Approved: NO
Most Recent Revision: YES
Current Version: NO
Status: Inactive
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