Standard: API 30-32009
TRANSIENT COGNITIVE DEFICITS AND HIGH-FREQUENCY HEARING LOSS IN WEANLING RATS EXPOSED TO TOLUENE
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In a previous experiment we found that weanling rats sub-chronically exposed to toluene by inhalation were deficient in learning a multisensory conditioned avoidance response (CAR) task and a tonc-intensity discrimination task when trained several hours after each daily 14-hour exposure ended. The present experiment was done to determine whether this deficit represented a residual pharmacologic effect or more persisting nervous system damage. Independent groups of rats were trained on the CAR task either during the last week of a 5-week exposure to 1400 or to 1200 ppm toluene (14 hr/day, 7 days/week) or during the first or third weeks after the exposures ended. None of the three groups of toluene-exposed rats were able to acquire the auditory CAR, whereas they learned the visual and somesthetic CARs. The frequency of the tone was 20 KHZ in this experiment, whereas it had been 4 KHZ in the previous experiment. Subsequent tests, in which the frequency and intensity of the tone were varied, revealed that hearing in these rats was unimpaired at 4 KHZ, slightly impaired at 8 KHZ, and markedly impaired at 12 KHZ and above. Thus, although toluene has been shown to be relatively innocuous as a toxicant, this new finding suggests that this solvent should be examined further in terms of its potential hazard, especially with regard to its frequent abuse.
|Organization:||American Petroleum Institute|
|Document Number:||api 30-32009|
|Most Recent Revision:||YES|