Standard: API 37-32486

A 14 DAY PALATABILITY AND STABILITY STUDY IN MICE WITH BENZENE ADMINISTERED IN DRINKING WATER - FINAL REPORT

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Scope:

INTRODUCTION

This study, conducted for the American Petroleum Institute, was designed to assess the feasibility of administering benzene in the drinking water to B5C3F1 mice {5/sex/group) at dose levels of 101, 305, and 700 mg/liter for a period of 14 days. Control animals (5/sex) received unadulterated drinking water. Following 14 days of administration, animals underwent a 7 day recovery period.

Body weight and water consumption measurements were performed on all animals for one week pretest and daily during the treatment and recovery period,

After 14 days of treatment and one week of recovery, all survivors were sacrificed and discarded.

Species and strain of test animals, method and route of test substance administration and dose levels were determined by the sponsor. This study was conducted at Bio/dynamics, Inc., Mettlers Road, East Millstone, New Jersey 08875. All raw data, the original study protocol, the original final report and a sample of the test substance are stored in the Archives of Bio/dynamics, Inc.

Organization: American Petroleum Institute
Document Number: api 37-32486
Publish Date: 1990-07-03
Page Count: 334
Available Languages: EN
DOD Adopted: NO
ANSI Approved: NO
Most Recent Revision: YES
Current Version: NO
Status: Inactive
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