Standard: API 37-32485

A 14 DAY PALATABILITY AND STABILITY STUDY IN RATS WITH BENZENE ADMINISTERED IN DRINKING WATER

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Scope:

INTRODUCTION:

This study, conducted for the American Petroleum Institute, was designed to assess the feasibility of administering benzene in the drinking water to 30 Fischer 344 rats (5/sex/group) at dose levels of 101, 305, and 700 mg/liter for a period of 15 days. Control animals (5/sex) received unadulterated drinking water.

Body weight and water consumption measurements were performed on all animals for one week pretest and daily during the treatment period.

After 15 days of treatment, all survivors were sacrificed and discarded. Species and strain of test animal, method and route of test substance administration and dose levels were determined by the sponsor. This study was conducted at Bio/dynamics, Inc., Mettlers Road, East Millstone, New Jersey 08875. All raw data, the original study protocol, the original final report and a sample of the test substance are stored in the Archives of Bio/dynamics, Inc.

Organization: American Petroleum Institute
Document Number: api 37-32485
Publish Date: 1990-07-03
Page Count: 265
Available Languages: EN
DOD Adopted: NO
ANSI Approved: NO
Most Recent Revision: YES
Current Version: NO
Status: Inactive
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