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CLSI MM21

Genomic Copy Number Microarrays for Constitutional Genetic and Oncology Applications

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Organization: CLSI
Publication Date: 1 August 2015
Status: active
Page Count: 50
scope:

This guideline provides recommendations for the appropriate performance, validation or verification, and interpretation of nucleic acid microarrays used primarily for cytogenetic applications to measure copy number (CN) imbalances, traditional array-based comparative genomic hybridization (aCGH), and single nucleotide polymorphism (SNP) arrays for CN imbalances and absence of heterozygosity (AOH). Both constitutional (prenatal/postnatal) and oncology applications are addressed.

The intended users of this guideline are clinical genetics laboratorians who perform cytogenetics and molecular genetics testing.

This guideline:

• Is not intended for research laboratorians

•┬áIs not intended to provide guidance to manufacturers

• Does not address methylation arrays, RNA expression microarrays, resequencing and genotyping arrays not intended for CN detection, microarrays for the diagnosis and monitoring of infectious diseases, or non-nucleic acid microarrays (eg, protein arrays)

Document History

CLSI MM21
August 1, 2015
Genomic Copy Number Microarrays for Constitutional Genetic and Oncology Applications
This guideline provides recommendations for the appropriate performance, validation or verification, and interpretation of nucleic acid microarrays used primarily for cytogenetic applications to...
August 1, 2015
Genomic Copy Number Microarrays for Constitutional Genetic and Oncology Applications
This guideline provides recommendations for the appropriate performance, validation or verification, and interpretation of nucleic acid microarrays used primarily for cytogenetic applications to...

References

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