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This International Standard specifies a method for determining the minimal inhibitory concentration (MIC) of a series of antibiotics applicable to bifidobacteria and non-enterococcal lactic acid bacteria (LAB).

NOTE Unlike the disk diffusion method, which is semi-quantitative, the frequently used broth microdilution method gives quantitative MICs of the test organism in a dilution series of the antibiotics. The lowest concentration of an antibiotic that prevents visible growth of a test organism is considered to be the MIC.

This International Standard recommends the broth microdilution method as the standard method.