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CLSI NBS04

Newborn Screening by Tandem Mass Spectrometry

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Organization: CLSI
Publication Date: 1 May 2017
Status: active
Page Count: 108
scope:

This guideline is intended to assist newborn screening (NBS) laboratory personnel in the routine use of tandem mass spectrometry (MS/MS) for the detection of metabolites that may indicate certain metabolic disorders using dried blood spot (DBS) specimens. The guideline describes:

• Preparation procedures for reagents, specimens, standards, and controls

• Calibration (both instrument and analyte)

• Standardization

• Control acceptance criteria

• Disorder profiles (interpretation of MS/MS spectra)

• External effects on results (eg, transfusion and total parenteral nutrition [TPN])

• Results reporting

• Second-tier testing

• Follow-up recommendations

This guideline:

• Is not intended to provide general information for screening on all conditions, only screening information related to MS/MS

• Does not cover confirmatory or diagnostic testing

Document History

CLSI NBS04
May 1, 2017
Newborn Screening by Tandem Mass Spectrometry
This guideline is intended to assist newborn screening (NBS) laboratory personnel in the routine use of tandem mass spectrometry (MS/MS) for the detection of metabolites that may indicate certain...

References

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