EFFECTS OF NITRATE AND / OR SULFATE AEROSOLS UPON CARDIOPULMONARY FUNCTION - FINAL REPORT
|Publication Date:||7 June 1976|
This is the final report of the first year of research conducted under the Coordinating Research Council CAPM-20-74 contract in the context of a three-year research program designed to determine the health effects of inhaling nitrate and sulfate salts in experimental animals. The influence of the cation component of these aerosols and the interaction effects of other atmospheric covariables (e.g. relative humidity, NO2, O3, and SO2) are to be studied. The coordinating Research Council had suggested the following approach using experimental animals:
(a) Define and demonstrate in the initial phase of the study the capability required to generate and analyze respirable nitrate and sulfate aerosols for purposes of conducting controlled inhalation exposures.
(b) Evaluate the respiratory consequences of acute and chronic exposure at ambient and effect levels of nitrate and/or sulfate salts, employing Na+, Zn+2, and NH4+ and possibly ferric cations.
(c) Determine the influence of relative humidity on the outcome of these exposures.
(d) Superimpose in an orderly manner each gas, i.e. NO2, O3 and SO2 on these aerosol exposures described in (b) and (c). This series of tests would shed light on the possible synergistic, additive, and antagonistic reactivity displayed by the various combinations of pollutants.