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CLSI M24

Susceptibility Testing of Mycobacteria, Nocardia spp., and Other Aerobic Actinomycetes

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Organization: CLSI
Publication Date: 1 November 2018
Status: active
Page Count: 110
scope:

M24 includes antimicrobial susceptibility testing (AST) protocols for three major categories of mycobacterial species:

Mycobacterium tuberculosis complex (MTBC)

• The slowly growing nontuberculous mycobacteria (SGM)

• The rapidly growing mycobacteria (RGM)

Also provided are:

• AST recommendations for Nocardia spp. and other aerobic actinomycetes

• Guidance on selecting first-line and, for some organisms, second-line antimicrobial agents for testing and reporting

• Instructions for performing the standard agar proportion (AP) method for MTBC and broth microdilution for mycobacteria and aerobic actinomycetes

• Molecular methods for detecting mutations associated with MTBC drug resistance

• QC protocols for each organism category

Testing and reporting recommendations and QC procedures apply to both reference methods and commercial shorter-incubation broth systems that have been regulatory organization cleared or approved for testing MTBC. This standard does not cover identification methods, nor does it provide an in-depth discussion of molecular test procedures. This standard is intended for use by hospital, public health, and referral laboratories that perform AST on MTBC, nontuberculous mycobacteria (NTM), Nocardia spp., and/or other aerobic actinomycetes.

Document History

CLSI M24
November 1, 2018
Susceptibility Testing of Mycobacteria, Nocardia spp., and Other Aerobic Actinomycetes
M24 includes antimicrobial susceptibility testing (AST) protocols for three major categories of mycobacterial species: • Mycobacterium tuberculosis complex (MTBC) • The slowly growing...
March 1, 2011
Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes; Approved Standard
CLSI document M24-A2 contains protocols for the susceptibility testing of three major categories of mycobacterial species (Mycobacterium tuberculosis complex [MTBC]; the slowly growing nontuberculous...
April 1, 2003
Susceptibility Testing of Mycobacteria, Nocardiae, and Other Aerobic Actinomycetes; Approved Standard
This document contains protocols for the susceptibility testing of three major categories of mycobacterial species: 1) Mycobacterium tuberculosis complex (MTBC), 2) the slowly growing, nontuberculous...
January 1, 1990
Antimycobacterial Susceptibility Testing; Proposed Standard
A description is not available for this item.

References

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