CLSI M24
Susceptibility Testing of Mycobacteria, Nocardia spp., and Other Aerobic Actinomycetes
Organization: | CLSI |
Publication Date: | 1 November 2018 |
Status: | active |
Page Count: | 110 |
scope:
M24 includes antimicrobial susceptibility testing (AST) protocols for three major categories of mycobacterial species:
• Mycobacterium tuberculosis complex (MTBC)
• The slowly growing nontuberculous mycobacteria (SGM)
• The rapidly growing mycobacteria (RGM)
Also provided are:
• AST recommendations for Nocardia spp. and other aerobic actinomycetes
• Guidance on selecting first-line and, for some organisms, second-line antimicrobial agents for testing and reporting
• Instructions for performing the standard agar proportion (AP) method for MTBC and broth microdilution for mycobacteria and aerobic actinomycetes
• Molecular methods for detecting mutations associated with MTBC drug resistance
• QC protocols for each organism category
Testing and reporting recommendations and QC procedures apply to both reference methods and commercial shorter-incubation broth systems that have been regulatory organization cleared or approved for testing MTBC. This standard does not cover identification methods, nor does it provide an in-depth discussion of molecular test procedures. This standard is intended for use by hospital, public health, and referral laboratories that perform AST on MTBC, nontuberculous mycobacteria (NTM), Nocardia spp., and/or other aerobic actinomycetes.
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