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ASTM International - ASTM E1163-10(2019)

Standard Test Method for Estimating Acute Oral Toxicity in Rats

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Organization: ASTM International
Publication Date: 1 February 2019
Status: active
Page Count: 3
ICS Code (Other pesticides and agrochemicals): 65.100.99
significance And Use:

5.1 This test method is of principal value in minimizing the number of animals required to estimate the acute oral toxicity (LD50). It also incorporates measures of variance (95 % CI) and a slope... View More

scope:

1.1 This test method determines the lethality (LD50 value, slope and 95 % confidence interval (CI)) and signs of acute toxicity from a material using a limited number of rats. The technique used in this test method is referred to as the "Stagewise, Adaptive Dose Method."2 This test method is an alternative to the classical LD50 test and is applicable to both liquids and solids.

1.2 This test method is not recommended for test materials which typically produce deaths beyond two days postdosing.

1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use.

1.4 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee.

Document History

ASTM E1163-10(2019)
February 1, 2019
Standard Test Method for Estimating Acute Oral Toxicity in Rats
1.1 This test method determines the lethality (LD50 value, slope and 95 % confidence interval (CI)) and signs of acute toxicity from a material using a limited number of rats. The technique used in...
February 1, 2016
Standard Test Method for Estimating Acute Oral Toxicity in Rats
5.1 This test method is of principal value in minimizing the number of animals required to estimate the acute oral toxicity (LD50). It also incorporates measures of variance (95 % CI) and a slope...
November 1, 2010
Standard Test Method for Estimating Acute Oral Toxicity in Rats
This test method is of principal value in minimizing the number of animals required to estimate the acute oral toxicity (LD50). It also incorporates measures of variance (95 % CI) and a slope from...
October 10, 2002
Standard Test Method for Estimating Acute Oral Toxicity in Rats
This test method is of principal value in minimizing the number of animals required to estimate the acute oral toxicity (LD50). This test method is inappropriate for materials typically producing...
October 10, 1998
Standard Test Method for Estimating Acute Oral Toxicity in Rats
1.1 This test method determines the lethality (LD50 value) and signs of acute toxicity from a material using a limited number of rats. The technique used in this test method is referred to as the...
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