scope:

This guideline provides direction for determining QC ranges, breakpoints, and interpretive categories for veterinary antimicrobial agents that have a direct action on microorganisms. This guideline applies to therapeutic antimicrobial agents intended to treat or control systemic or organ-specific infectious diseases processes in nonhuman, animal species (terrestrial or aquatic). The intended audience includes sponsors (eg, antimicrobial agent manufacturers) planning to submit data to establish or revise antimicrobial susceptibility testing (AST) QC ranges, breakpoints, and interpretive categories for inclusion in CLSI AST documents. Guidance presented in VET02 applies only to CLSI procedures and documents. The methods described in this guideline do not apply to:

• Antimicrobial agents used for growth promotion or prophylaxis (disease prevention)

− See CLSI document VET01¹ for details.

• Antimicrobial agents formulated for direct administration to skin or mucous membranes (eg, topical antimicrobial agents such as lotions, creams, ointments, or eye drops) or for inhalation