4.1 "Stand-alone" laboratories rarely generate or handle large volumes of hazardous substances. However, the safe handling and disposal of these substances is still a matter of concern. Since the promulgation of the Resource Conservation and Recovery Act (RCRA) of 1976, more attention has been given to the proper handling and disposal of such materials. States may adopt more stringent requirements than required under RCRA. To keep track of this, EPA classifies state regulatory language as: (1) authorized, (2) procedural/enforcement, (3) broader in scope, and (4) unauthorized, and it publishes notices concerning the first three in the Federal Register.

4.2 Laboratory management should designate an individual who will be responsible for waste disposal and must review the RCRA guidelines, in particular:
40 CFR 261.3-definition of a hazardous waste,
40 CFR 261.33-specific substances listed as hazardous,
40 CFR 262-generator requirements and exclusions, and proper shipping and manifesting procedures.

4.3 Because many laboratory employees could be involved in the proper treatment and disposal of laboratory chemicals and samples, it is recommended that a safety and training program be designed and presented to all regarding procedures to follow in the treatment and disposal of designated laboratory wastes. This recommendation is required in the United States by the EPA (40 CFR 265.16). For those who pack and ship, Hazardous Materials Shipper training is also required by DOT (49 CFR 172.203).5

4.4 If practical and economically feasible, it is recommended that all laboratory waste be either recovered, re-used, or disposed of in-house. However, should this not be the case, other alternatives are presented. This guide is intended only as a suggested organized method for classification, segregation, and disposal of chemical laboratory waste. A university can set up its own chemical distributor to take orders from departments, order in economical quantities, sell at prorated bulk price plus expenses, and take back what is unused. For an example of a university central facility for minimizing over-ordering, storing chemical packages between uses, and disposing of hazardous wastes, see the University of Vermont website (http://www.uvm.edu/safety/lab/waste).

4.5 The handling of laboratory samples, especially those received in large numbers or quantities from a specific source, can often be accommodated by returning the material to the originator for processing and potentially combining with larger quantities of the same material for recycling or disposal. Shipments of hazardous waste, including samples, are subject to RCRA regulations that do not apply to shipments of what is similar but not waste-like. A sample that was not a waste as received, and has not been contaminated or labeled as waste, need not be a waste when it is returned.

4.6 The small quantity generator exclusion (40 CFR 261.5) applies to some laboratories (those which generate less than 100 kg per month, ~25 gal liquid). It is important to note that not every state allows the small quantity exclusion in this amount. Even so, the professional laboratory manager/supervisor and their employers must balance the importance of (1) protecting human health and the environment from the adverse impact of potential mismanagement of small quantities of hazardous waste with (2) the need to hold the administrative and economic burden of management of these wastes under RCRA within reasonable and practical limits. Additionally, all lab supervisors should be aware of current local, state, and federal regulations, and of specific hazardous waste management facility criteria. Special rules have been made for some academic laboratories; see 40 CFR 262.100-108. Commercial services to facilitate Internet access to the regulations, and even to alert users to changes in chosen parts of these regulations, are available.6