scope:

This document addresses the following:

a) the confidentiality of personal information for the customer and the laboratory;

b) the laboratory safety requirements;

c) the calibration sources and calibration dose ranges useful for establishing the reference doseresponse curves that contribute to the dose estimation from CBMN assay yields and the detection limit;

d) the performance of blood collection, culturing, harvesting, and sample preparation for CBMN assay scoring;

e) the scoring criteria;

f) the conversion of micronucleus frequency in BNCs into an estimate of absorbed dose;

g) the reporting of results;

h) quality assurance and quality control;

i) informative annexes containing sample instructions for customers, sample questionnaire, a microscope scoring data sheet, and a sample report.