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CRC - Arthritis: Pathophysiology, Prevention, and Therapeutics

Organization: CRC
Publication Date: 5 April 2011
Page Count: 586


Medical science is advancing at a galloping pace. There is explosion of knowledge and information in all disciplines of medicine. In this book, we have covered cutting-edge information on arthritic diseases and their treatment. Arthritis is a debilitating disease that causes pain, inflammation, and loss of movement of the joints. The term arthritis literally means joint inflammation (arth = joint, ritis = inflammation). People of all ages, including children and young adults, can develop arthritis. Inflammation and inflammatory responses are key factors for causing swelling, redness, pain, and loss of movement in the affected areas. Arthritis is usually chronic and refers to more than 100 different kinds of arthritis that can affect the different parts of the body. It is important to know that in addition to the joints, some forms of arthritis are associated with diseases of other tissues and organs in the body. Also, arthritis has been shown to have direct correlations with obesity, diabetes, and cardiovascular dysfunctions.

We designed this book Arthritis: Pathophysiology, Prevention, and Therapeutics with a focused approach to cover the mechanistic aspects to understand the disease pathophysiology and treatment opportunities. One of the major goals and objectives of this book is to help readers understand the intricate aspects of arthritis and inflammatory responses, its consequences, the economic burden, and its huge impact on human society.

The book starts with a section on pathophysiology, which consists of seven chapters providing insight of rheumatoid arthritis, osteoarthritis, and psoriatic arthritis. Because arthritis has a very close relationship with other debilitating diseases including obesity, diabetes, and cardiovascular dysfunctions as well as with disability, we have dedicated the second section to consequences for providing a better perception of the importance of such diseases.

The third section focuses on antiarthritic drugs. This section starts with an overview and update on antiarthritic drug development by Dr. Micheal G. Lyon from Stanford University School of Medicine, which is followed by a chapter on nonsteroidal anti-inflammatory drugs. The third chapter highlights the diverse biologics involved in arthritic diseases. The fourth chapter discusses the topical applications for pain and arthritic diseases. The last two chapters deliver an overview on hyaluronic acid and hyaluronan in osteoarthritis and rheumatoid arthritis.

The fourth section delivers an array of natural therapeutic interventions in osteoarthritis and rheumatoid arthritis. This section gives an overview of glucosamine and chondroitin salts, hyaluronic acid, methylsulfonylmethane, S-adenosyl-l-methionine, undenatured type II collagen, curcumin, red pepper, capsaicin, Boswellia serrata, shark cartilage, omega-3 fatty acids, fish oil, plant-derived oils, avocado, bromelain, red ginger, Tripterygium wilffordii, dehydroepiandrosterone, green lipid mussel, abalone, rosmarinic acid mint, and pycnogenol.

The fifth section discusses orthopedic approach. This small section discusses the effect of total knee arthroplasty for osteoarthritis.

The sixth section discusses nonpharmacological interventions. The first chapter in this section discusses the influence of physical exercise in arthritis. This section also has an outstanding discussion on acupuncture, which is now globally used, and nonpharmacological intervention by physical exercise and rehabilitative strategy.

Finally, the seventh section is a commentary discussing the correlation between arthritis and the aging society and how exercise, nutrition, and preventative strategies can help the world and mankind in promoting human health.