CRC - Stem Cells and Bone Tissue

Organization: CRC
Publication Date: 23 January 2013
Page Count: 419


Bone diseases, characterised by either fractures, stunting, loss of mineral composition or strength, are important causes of morbidity and mortality. For example worldwide there are 9 million new cases of fractures due to osteoporosis annually and this has increased by 50% in the past 2 decades. As the population ages, these fi gures will further increase, imposing burdens on individuals, communities, and health providers. As a result, new treatments and strategies are continually being developed to prevent bone diseases occurring and also to treat such conditions. Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. However, obtaining information on stem cells per se and their usage and applications in treating skeletal disorders is currently problematic, as such text-based material is either sporadic or directed towards the expert. This book Stem Cells and Bone Tissue is designed to address such limitations. It is multidisciplinary and covers all scientifi c levels. Stem Cells and Bone Tissue has three major sections:

Section 1: Introductory Text and Sources of Stem Cells for Skeletal Tissue

Section 2: Cellular and Molecular Aspects

Section 3: Conditions, Applications, Treatments and Repairs

The simplistic nature of the main section headings, however, should not detract from the fact that individual chapters are highly detailed. Coverage includes for example, general aspects of stems cells, sources of stems cells, isolation and purifi cation, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4 signalling, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.

There are three distinguishing features of Stem Cells and Bone Tissue that sets it apart from other scientifi c texts. As well as an Abstract, each chapter has one or more Key Facts which expands areas of interest for the novice. There are also at least fi ve defi nitions and explanations of key terms or words used in each chapter. Finally, each chapter is summarised with at least fi ve bullet points. The book is well illustrated with numerous fi gures and tables and the entire book has an excellent index. As a consequence of these features the readership is designed to be broad, from the novice to leading expert.

Contributors of Stem Cells and Bone Tissue are all either international or national experts, leading authorities or are carrying out ground breaking and innovative work on their subject. The book is an essential text for orthopaedic specialists, doctors and clinicians, surgeons, pathologists, research scientists, molecular biologists, biochemists, health care professionals and general practitioners as well as those interested in disease or bone tissues in general.