ASTM International - ASTM E758-98(2002)
Standard Test Method for Mammalian Acute Percutaneous Toxicity (Withdrawn 2010)
|Publication Date:||10 October 2002|
|ICS Code (Biology. Botany. Zoology):||07.080|
significance And Use:
Generally, direct extrapolation of the results of animal to human toxicity cannot be made. This test method can be used for initial percutaneous toxicity studies on a single species. Ideally, the... View More
Generally, direct extrapolation of the results of animal to human toxicity cannot be made. This test method can be used for initial percutaneous toxicity studies on a single species. Ideally, the assessment of potential hazard to man requires the use of several mammalian species, such as rabbit, rat, guinea pig, and swine.
This method can be used to determine the dermal toxicity of technical chemicals, manufacturing use products or formulations.
Note 1-This test method is not intended to limit innovative approaches or modifications deemed desirable by individual investigators.
Some materials are not sufficiently toxic to mammals to be accurately measurable by this method. This may also be true when testing low concentrations of otherwise toxic formulations. Because of practical limitations in the amount of surface area of an animal that can be exposed and exposure times, only semiquantitative data can be obtained for such materials using this test. However, sufficient data should be generated by the use of the method to permit a reasonable estimate of the level of risk to humans.
Test materials that are a gas or highly volatile do not need to be tested.View Less
1.1 This laboratory test method is designed to test the acute toxicity of single applications of material(s) applied to the skin of mammals.
1.2 This test method is applicable to individual chemicals, simple and complex mixtures, and finished products, such as pesticides, repellents, and biocides.
1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.