Bone Graft Substitutes and Bone Regenerative Engineering
|Publication Date:||1 January 2014|
We are truly delighted to write the foreword for Bone Graft Substitutes and Bone Regenerative Engineering. Edited by Professor Cato Laurencin and Professor Tao Jiang, the book exemplifies the use of Convergence in the design of new technologies for bone repair and regeneration. Over the past several decades, bone grafting has been a common task for orthopedic surgeons and each year millions of patients receive bone grafts worldwide. As the first generation bone grafting products, autologous bone grafts have been considered the gold standard; however, these grafts are severely limited by supply. Since the late 1980s, Dr. Laurencin and others pioneered a new area of research called bone tissue engineering (BTE). BTE has gradually emerged as a promising alternative to bone autografts in treatment scenarios. As such, several engineered products such as MicroFuse® have been inspired by technologies that originated in Dr. Laurencin's laboratory. Nevertheless, various challenges in bone tissue engineering still exist, such as the need for advanced biomaterials, appropriate and reliable cell sources, and a thorough understanding of regenerative biology and tissue morphogenesis as new technologies influencing regeneration. Therefore, many believe that Regenerative Engineering, a new field described by Dr. Laurencin with a focus on Convergence integrating biology, biomedical science, physics and engineering, serves as the future of tissue engineering. In the past decades, the Raymond and Beverly Sackler Foundation has supported and endowed numerous programs that embrace the concept of Convergence in scientific research. We are happy to have supported the creation of the Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences at the University of Connecticut Health Center directed by Dr. Laurencin to support his efforts in defining the new field of Regenerative Engineering.
This timely book provides a well-rounded and articulate summary of the present status of using allogeneic, xenogenic, and synthetic bone graft substitutes to reconstruct bone tissues. Specifically, fifteen concise and comprehensive chapters are prepared by experts in their fields from both academia and industry. These chapters encompass numerous topics discussing the use of a wide selection of bone graft substitutes ranging from bone allografts and xenografts derived from human and animal tissues to synthetic biomaterials, cells, and growth factors. While many of these bone graft substitutes have experienced great clinical successes and have helped improve patients' health, challenges still remain to reconstruct functional bone tissue mimicking natural bone morphogenesis. This is precisely where bone Regenerative Engineering has a niche and a significant role to play. In this regard, the book also includes a number of chapters discussing frontier paradigms such as advanced materials, stem cells, nanobiotechnology, and developmental biology aiming to regenerate bone tissue in a more natural and effective way. Convergent technologies integrating the aforementioned disciplines promise to continue extending research frontiers, pushing bone regeneration therapies towards a more personalized approach that can truly benefit individual patients.
This book presents an outstanding view of the subject. It will appeal to a broad audience including researchers, clinicians, and regulatory specialists in both academia and industry and will serve as a valuable resource to these professionals. We believe that this book will be a welcome addition to personal collections, libraries, and classrooms throughout the world.